Treating the Periphery to Ameliorate Neurodegenerative Diseases
نویسندگان
چکیده
Abnormalities in the kynurenine pathway are associated with neurodegenerative disorders. Zwilling et al. (2011) show that inhibition of kynurenine 3-monooxygenase in the body's periphery leads to an increase in kyneuric acid, a neuroprotective compound, in the brain. This intervention ameliorates neurodegeneration in mouse models of Alzheimer's disease and Huntington's disease.
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ورودعنوان ژورنال:
- Cell
دوره 145 شماره
صفحات -
تاریخ انتشار 2011